![]() ![]() ZnT8A has been detected in 60–80% of Caucasian 4, 5, 6, 7, 8, 9 and 24–70% of Asian populations with T1D 10, 11. Zinc transporter-8 (ZnT8), the product of the SLC30A8 gene, is a secretory granule membrane protein of the pancreatic beta cells that was recently identified as an autoantigen in T1D 4.Īutoantibodies to ZnT8 (ZnT8A) complement the established set of type 1 diabetes-associated autoantibodies to insulin (IAA), glutamic acid decarboxylase (GAD65A), and protein tyrosine phosphatase (insulinoma-2 antigen antibody, IA-2A), which are important for predicting and confirming the T1D diagnosis 5. Beyond diagnosis, autoantibody determinations may also be useful for assessing the immunological impact of therapeutic interventions targeting autoreactive T- and B-cells 3. Humoral auto-reactivity typically precedes clinical disease by months or years, and the progression to clinical manifestations is marked by intramolecular and intermolecular epitope spreading 1, 2. The major molecular targets of type 1 diabetes (T1D) autoimmunity have been identified by islet autoantibody research in humans, providing insight into the etiology, pathogenesis, and natural history of the disease. SLC30A8 rs2466293 was associated with T1D predisposition in non-European descents. Conclusion ZnT8A detection increases T1D diagnosis rate even in mixed populations. ![]() The diabetes duration-dependent decline in ZnT8A frequency was similar to GAD65A and IA-2A. Znt8A and IA2A frequencies and titers were independent of gender and ethnicity, whereas GAD65A titers were greater in females. ZnT8A was the only antibody in 8.4% of patients. Results: Znt8A was detected in 68.7% of recent-onset T1D patients and 48.9% of the entire patient cohort, similar to GAD65A (68.3% and 47.2%) and IA-2A (64.8% and 42.4%) positivities respectively. ZnT8 triple antibody was measured by ELISA glutamic acid decarboxylase (GAD65A) and protein tyrosine phosphatase (IA-2A) autoantibodies by radioimmunoassay. Patients with T1D (n = 629 diabetes duration = 11 (6–16) years) and 651 controls were genotyped for SLC30A8 rs16889462 and rs2466295 variants (BeadXpress platform). Therefore, we evaluated the relevance of ZnT8A for type 1 diabetes (T1D) diagnosis and the role of ZnT8 coding gene (SLC30A8) in T1D predisposition. There is a scarcity of data of zinc transporter-8 autoantibody (ZnT8A) on mixed populations such as Brazilian. ![]()
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